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Meeting MS&T22: Materials Science & Technology
Symposium 3D Printing of Biomaterials and Devices
Presentation Title Implant Optimization Guided by Biomimetic Insight
Author(s) Malcolm L. Snead
On-Site Speaker (Planned) Malcolm L. Snead
Abstract Scope Implants use has expanded and with it,the prevalence of peri-implant disease that shortens implant life and leads to failure. Peri-implant disease results from microbiota dysbiogenesis triggering a host immune inflammatory response that destroys tissue. At an incidence of 14.5%, and over 3 million implants placed, growing by 500,000/year, reduced service life ending in failure will adversely impact public health and increase health care costs. We developed an antimicrobial bifunctional peptide film to slow disease progression. Based on a high-affinity titanium binding peptide that anchors the anti-microbial peptide to the implant surface, greater than 98% coverage is achieved in <2 minutes even in the presence of contaminating protein, to produce a film durable to mechanical brushing that kills >90% of bacterial. This non-surgical approach improves oral health by delivering a simple to apply/reapply multiple times using a water-delivered bifunctional peptide film serving to control microbial dysbiogenesis and reduce disease progression.


3-D Printing in Regenerative Engineering
3D Bioprinting with Engineered Living Materials for Advanced Biofabrication
3D Printing Integrated with Controlled Delivery for In Situ Tissue Engineering of Complex and Inhomogeneous Tissues from Endogenous Stem/Progenitor Cells
3D Printing of Nanomaterials-based Biomedical Electronics
3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
3D Printing Strategies to Fabricate Complex Scaffolds for Tissue Engineering Applications
Additive Manufacturing Process Simulation of Polyetherimide Porous Scaffolds for Bone Tissue Engineering Applications
Biohybrid Functional Material Design by Engineered Peptides
C-1: Surface Treatment of Titanium by Alkali treatment and Magnesium Deposition for Orthopedic Application
Effect of Printing Parameters on 3D-printed Biodegradable Biopolymer-metal Composite Material
Effect of Sr2+ and Ca2+ ions on 3D printed Beta Tricalcium-Phosphate/Alginate Composite Scaffolds for Bone Tissue Engineering
Implant Optimization Guided by Biomimetic Insight
Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
Laser-Based 3D Printing for Medical Applications
Mechanical and Electrical Properties of 3D Printed Wearable Structures
Periodic Cellular Ceramic Structures by Replication of Additive Manufactured Templates
Selective Artificial Neural Network by Targeted Delivery of Neuronal Cells Using Magnetically Controlled 3D Printed Microrobots
Sheet Lamination Additive Manufacturing (SLAM) – A Viable Approach to Resorbable 3D Constructs for Bone Tissue Engineering
Solvent Cast 3D Printing with Different Molecular Weight Polymers
The Regulatory Roles of the Substrate Microenvironment in Cancer Progression in Tissue Engineering Scaffolds

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