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Meeting MS&T22: Materials Science & Technology
Symposium 3D Printing of Biomaterials and Devices
Presentation Title 3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
Author(s) Syam P. Nukavarapu, Aleksandra Golebiowska
On-Site Speaker (Planned) Syam P. Nukavarapu
Abstract Scope Osteochondral (OC) defect repair remains a significant clinical challenge due to the complexity of the OC unit. Traditional fabrication methods are often met with limitations in replicating the unique structure of the OC tissue. Three-dimensional (3D) printing allows for development of precise microstructural architecture. In this study, a series of zonal-structured scaffolds were fabricated via 3D printing with controlled porosity to support each layer of the OC unit along with a graded scaffold intended to enable the formation of the OC interface. Scaffolds demonstrated controlled hierarchical structure within each region and structural variation along the length with structural integrity and mechanical properties within the range of trabecular bone. Scaffolds were also developed with regional compositional organization through co-deposition of polymeric framework and a cell-laden hydrogel demonstrating selective homogenous distribution of the required cell population. This work developed controlled and reproducible multi-regional and gradient scaffolds for complex tissue engineering applications.


3-D Printing in Regenerative Engineering
3D Bioprinting with Engineered Living Materials for Advanced Biofabrication
3D Printing Integrated with Controlled Delivery for In Situ Tissue Engineering of Complex and Inhomogeneous Tissues from Endogenous Stem/Progenitor Cells
3D Printing of Nanomaterials-based Biomedical Electronics
3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
3D Printing Strategies to Fabricate Complex Scaffolds for Tissue Engineering Applications
Additive Manufacturing Process Simulation of Polyetherimide Porous Scaffolds for Bone Tissue Engineering Applications
Biohybrid Functional Material Design by Engineered Peptides
C-1: Surface Treatment of Titanium by Alkali treatment and Magnesium Deposition for Orthopedic Application
Effect of Printing Parameters on 3D-printed Biodegradable Biopolymer-metal Composite Material
Effect of Sr2+ and Ca2+ ions on 3D printed Beta Tricalcium-Phosphate/Alginate Composite Scaffolds for Bone Tissue Engineering
Implant Optimization Guided by Biomimetic Insight
Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
Laser-Based 3D Printing for Medical Applications
Mechanical and Electrical Properties of 3D Printed Wearable Structures
Periodic Cellular Ceramic Structures by Replication of Additive Manufactured Templates
Selective Artificial Neural Network by Targeted Delivery of Neuronal Cells Using Magnetically Controlled 3D Printed Microrobots
Sheet Lamination Additive Manufacturing (SLAM) – A Viable Approach to Resorbable 3D Constructs for Bone Tissue Engineering
Solvent Cast 3D Printing with Different Molecular Weight Polymers
The Regulatory Roles of the Substrate Microenvironment in Cancer Progression in Tissue Engineering Scaffolds

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