|About this Abstract
||MS&T22: Materials Science & Technology
||3D Printing of Biomaterials and Devices
||3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
||Syam P. Nukavarapu, Aleksandra Golebiowska
|On-Site Speaker (Planned)
||Syam P. Nukavarapu
Osteochondral (OC) defect repair remains a significant clinical challenge due to the complexity of the OC unit. Traditional fabrication methods are often met with limitations in replicating the unique structure of the OC tissue. Three-dimensional (3D) printing allows for development of precise microstructural architecture. In this study, a series of zonal-structured scaffolds were fabricated via 3D printing with controlled porosity to support each layer of the OC unit along with a graded scaffold intended to enable the formation of the OC interface. Scaffolds demonstrated controlled hierarchical structure within each region and structural variation along the length with structural integrity and mechanical properties within the range of trabecular bone. Scaffolds were also developed with regional compositional organization through co-deposition of polymeric framework and a cell-laden hydrogel demonstrating selective homogenous distribution of the required cell population. This work developed controlled and reproducible multi-regional and gradient scaffolds for complex tissue engineering applications.