About this Abstract |
Meeting |
2020 TMS Annual Meeting & Exhibition
|
Symposium
|
2020 Technical Division Student Poster Contest
|
Presentation Title |
SPG-19: In-Vitro Prediction of Material Performance of Central Venous Catheters (CVCs) Exposed In-Vivo |
Author(s) |
Maren K. Fossum, Zozan Tunc, Javier Sanchez, Cristoph Burgstaller, Emma Strömberg, Gunilla Björling, Ragnhild E. Aune |
On-Site Speaker (Planned) |
Maren K. Fossum |
Abstract Scope |
Treating long-term diseases such as cancer requires implantation of a Central Venous Catheter (CVC) for administration and distribution of cytostatic drugs in the human body. The CVC is at the same time linked to an increased risk of complications such as thrombosis, mechanical failure and infections.
In the present study an integrated and validated methodology for risk management of CVCs has been realised through the development of a modular testbed. Furthermore, the loss of performance due to material-drug-biological system interactions have been evaluated over time, i.e. under controlled conditions and in an environment simulating human body conditions. The obtained in-vitro results were compared to the results obtained from ex-implanted CVCs (in-vivo results). Good correlation was established to exist between in-vitro and in-vivo results, validating the testbed methodology for prediction of material properties in the present case. Overall clear indications of less than acceptable performance after clinical exposure were concluded. |
Proceedings Inclusion? |
Undecided |