About this Abstract |
Meeting |
2020 TMS Annual Meeting & Exhibition
|
Symposium
|
2020 Technical Division Student Poster Contest
|
Presentation Title |
SPG-20: Magnetic Activation of Ferromagnetic Fibre Network for Bone Regeneration |
Author(s) |
Galit Katarivas Levy, Mark Birch, Roger Brooks, Athina Markaki |
On-Site Speaker (Planned) |
Galit Katarivas Levy |
Abstract Scope |
The project focuses on the magneto-active, porous implant coatings made of ferritic stainless-steel fibres, seeded with human osteoblast. When the coating is actuated in-vivo by an external magnetic field, it deforms elastically as the ferromagnetic fibres tend to align along the field direction, imposing strains to in-growing bone tissue. The present work aims to generate in-vitro proof of the osteoconductive potential of such magneto-mechanically actuated scaffolds. In this study, mineralization, gene and protein analyses reveal that the actuated networks exhibit higher extracellular matrix production and express higher levels of osteogenesis markers than the static controls at the 3-week time point. The results imply that the cells filling the inter-fiber spaces are able to sense and react to the magneto-mechanically induced strains facilitating osteogenic differentiation and maturation. Collectively, the proposed magnetic actuation strategy has the potential to promote osteogenesis and can pave the way for further applications in bone tissue engineering. |
Proceedings Inclusion? |
Undecided |