| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Mechanical Properties of Tough, Mechanochemically Active Hydrogels and Hydrogel-based Composites |
| Author(s) |
Jamie J. Kruzic, Yuwan Huang, Bhakthi Jayathilaka, Shariful Islam, Meredith Silberstein, Kristopher A. Kilian |
| On-Site Speaker (Planned) |
Jamie J. Kruzic |
| Abstract Scope |
Inspired by how forces in biological tissues guide matrix deposition, we have developed bioinspired hydrogel chemistry where an applied force facilitates molecule immobilization from the surrounding environment. We have demonstrated this concept using poly(ethylene glycol) (PEG) hydrogels that are formed through model force-responsive disulphide linkages where bond scission is able to catalyze reactions with complementary groups (e.g., acryloyl and/or maleimide). Furthermore, recognizing that single network hydrogels suffer from inherent brittleness that make them poor choices for load bearing bioengineering applications, we have incorporated these mechanochemically active networks into tough, double network hydrogels reinforced with alginate to mimic the interpenetrating networks of biomolecules found in living tissue. This presentation will report on the mechanical and functional properties of single and double network mechanochemically active hydrogels and how different network structures and composite architectures control the mechanical properties and mechanochemical response. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Polymers |