| Abstract Scope |
Recently, orthopedic implants focus on the effect of osteointegration and prevention of implant-associated infections (IAI). Anodic oxidation was applied to β-type Ti-28Nb-11Ta-8Zr (TNTZ) for fabricating crystallized nanoporous oxide (NPTNTZO(c)) on the surface, which demonstrating bone-mimetic young’s modulus, biocompatibility, and antibacterial capability in previous study. However, in-vivo test is a crucial part for bone-related implants.
In this study, the rats were randomly divided into NPTNTZO(c) and control group for 4,8, and 12 weeks. After sacrificed, NPTNTZO(c) exhibited larger ultimate pull-out load in biomechanical test. Besides, 8 and 12-weeks groups even exceeded 200N. The reason is that rough surface could enhance bone ingrowth and osteoconductive property. The results of histological and micro-CT analysis also manifested corresponding performance. Next, NPTNTZO(c)/AgNPs, carried with silver nanoparticles into nanostructure, could increase antimicrobial ability in vivo. In essence, NPTNTZO(c)/AgNPs show excellent osteointegration and resistance of bacterial infections with prospective clinical outcomes. |