| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Investigating the Remodeling of the Cellular and Collagen Tissue Structures of the Optic Nerve Head in Mouse Models of Glaucoma |
| Author(s) |
Thao D. Nguyen |
| On-Site Speaker (Planned) |
Thao D. Nguyen |
| Abstract Scope |
Glaucoma is a blinding disease characterized by progressive damage of retinal ganglion cell axons at the level of the lamina cribrosa in the optic nerve head (ONH). We hypothesize that a chronic elevation in the intraocular pressure cause the tissues of the ONH to remodel in ways that are detrimental to the physiological support of the axons leading to axonal dysfunction and death In this talk, I will describe our efforts to characterize the collagen structure and mechanical behavior of the peripapillary sclera and the astrocytic lamina of mouse eyes using advanced x-ray scattering, optical imaging, and digital image/volume correlation methods. We also developed image processing algorithms to characterize the structure of the collagen fibers in the sclera and astrocytic network in the lamina. Our findings suggest a complicated interplay between the remodeling of the cellular and extracellular tissues of the ONH to recover strain homeostasis in the lamina cribrosa. |
| Proceedings Inclusion? |
Planned: |