ProgramMaster Logo
Conference Tools for 2021 TMS Annual Meeting & Exhibition
Login
Register as a New User
Help
Submit An Abstract
Propose A Symposium
Presenter/Author Tools
Organizer/Editor Tools
About this Abstract
Meeting 2021 TMS Annual Meeting & Exhibition
Symposium Biological Materials Science
Presentation Title Conformational Transition of G-Actin Subunits Controls the Deformation Behavior of Actin Filament
Author(s) Sharad V Jaswandkar, Kalpana S Kattti, Dinesh Katti
On-Site Speaker (Planned) Sharad V Jaswandkar
Abstract Scope Actin filaments (F-actins) are filamentous intracellular proteins present in eukaryotic cells, known for regulating cellular functions including muscle contraction, cell-motility, cell-division, cell-movement, cell-signaling, and formation of cell-junctions. In actin assembly dynamics, actin filaments are severed constitutively by an essential regulatory protein; ADF/Cofilin. Several studies report mechanical properties of F-actins, however, the fundamental mechanisms governing F-actin response to deformation are unknown. Here, we present an in-depth analysis of the F-actin deformation using steered-molecular-dynamics (SMD) simulations. Our findings demonstrate that F-actin deformation response is regulated by the pattern of dissociation of conformational locks at intra-strand and inter-strand G-actin interfaces. F-actin elongation enabled salt bridge formation at the inter-strand interfaces improves the G-actin-G-actin bond strength. Furthermore, we report an inter-strand serrated locking pattern between G-actin subunits, restricting their relative movement, and enabling ability of F-Actin to resist deformation. We also observe that ADF/Cofilin causes structural transmutations in F-actin, thus altering its physical properties.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Composites, Polymers

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

A Novel Cardiac Patch for Treating Myocardial Infarction
Assessing the Role of Loading Direction on the Compressive Response and Deformation Mechanism in Bioinspired Multilayered Composites
Bamboo Fibre-reinforced Mycelium Composites for Sustainable Structures
Bioinspired Design of Fracture Resistant Layer-by-Layer Composite Structure
Bioinspired Graphene Nanocomposites with Exceptionally High Mechanical Performance
Biomineralized Low-density Structural Materials
Bone-Mimetic β-TNTZ Alloy for Osteointegration and Antibacterial Property: A Rat Animal Model
Cancer Testbed for Breast and Prostate Cancer Bone Metastasis
Conformational Transition of G-Actin Subunits Controls the Deformation Behavior of Actin Filament
Employing Electric Field in the Fabrication of Directionally Porous Ice-templated Ceramics
Euplectella Aspergillum: Multiscale Structural Characterization, Quantification and Micromechanical Properties
Freeze Casting of Bioinspired Materials with Extrinsic Control Techniques
Internal Strain Mapping for Native and Implanted Glenoids
Investigating the Effect of Morphological Parameters on the Sound-Induced Mechanical Response of Mosquito Antennae
Investigating the Remodeling of the Cellular and Collagen Tissue Structures of the Optic Nerve Head in Mouse Models of Glaucoma
Mechanical Properties of Tough, Mechanochemically Active Hydrogels and Hydrogel-based Composites
Microstructural Variations in Mammalian Enamel: An Exploration of Decussation from the Micro- to the Macro-scale
Nanotechnology Enhanced Novel Bioresorbable Zn Alloy Implant for Short Bowel Syndrome Treatment
Negative Compressibility Architected Materials for Novel Cardiac Patches
Novel Zn-Fe-Si Alloy as Biodegradable Stent Material
On the Structure and Mechanical Properties of Aprismatic Enamel in Crocodilian Teeth
Strain Field Mining of Steady-state Tearing Fields in Thin Film, Heterogeneous Fiber Networks
Tapes: An Overlooked Biological Material Archetype
Tough Enlightenments From the Prayer Bead: Fracture-tolerant Endocarp of Elaeocarpus Ganitrus Seed (Rudraksha)
Understanding Heterogeneity in Bone Adaptation Following Exercise
Understanding the Role of Ridged Geometries in the Telson of the Mantis Shrimp

Questions about ProgramMaster? Contact programming@programmaster.org