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Meeting 2021 TMS Annual Meeting & Exhibition
Symposium Biological Materials Science
Presentation Title Nanotechnology Enhanced Novel Bioresorbable Zn Alloy Implant for Short Bowel Syndrome Treatment
Author(s) Jingke Liu, Zeyi Guan, Yuxin Zeng, Chase Linsley, James C.Y. Dunn, Bejamin M Wu, Xiaochun Li
On-Site Speaker (Planned) Jingke Liu
Abstract Scope Short Bowel Syndrome (SBS) is a calamitous genetic disease that affects thousands of lives every year. Patients diagnosed with SBS have malabsorption and are deprived of the ability to absorb nutrition normally. Recently, a novel treatment method is developed by researchers, which uses endoscopically inserted compression springs to lengthen the diseased small intestines. However, the springs currently under development are not biodegradable. Zinc, as a recent popular biodegradable material with suitable corrosion rate and biocompatibility, poses as a promising candidate material for this application. However, zinc lacks the mechanical strength (weak yield strength and low Young’s modulus) to be employed as effective spring devices. In this study, we successfully designed and fabricated a biodegradable Zn-based alloy nanocomposite device with enhanced and tunable mechanical strengths, as well as fixture structures to meet within vivo animal testing requirements of spring devices.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Nanotechnology, Other

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

A Novel Cardiac Patch for Treating Myocardial Infarction
Assessing the Role of Loading Direction on the Compressive Response and Deformation Mechanism in Bioinspired Multilayered Composites
Bamboo Fibre-reinforced Mycelium Composites for Sustainable Structures
Bioinspired Design of Fracture Resistant Layer-by-Layer Composite Structure
Bioinspired Graphene Nanocomposites with Exceptionally High Mechanical Performance
Biomineralized Low-density Structural Materials
Bone-Mimetic β-TNTZ Alloy for Osteointegration and Antibacterial Property: A Rat Animal Model
Cancer Testbed for Breast and Prostate Cancer Bone Metastasis
Conformational Transition of G-Actin Subunits Controls the Deformation Behavior of Actin Filament
Employing Electric Field in the Fabrication of Directionally Porous Ice-templated Ceramics
Euplectella Aspergillum: Multiscale Structural Characterization, Quantification and Micromechanical Properties
Freeze Casting of Bioinspired Materials with Extrinsic Control Techniques
Internal Strain Mapping for Native and Implanted Glenoids
Investigating the Effect of Morphological Parameters on the Sound-Induced Mechanical Response of Mosquito Antennae
Investigating the Remodeling of the Cellular and Collagen Tissue Structures of the Optic Nerve Head in Mouse Models of Glaucoma
Mechanical Properties of Tough, Mechanochemically Active Hydrogels and Hydrogel-based Composites
Microstructural Variations in Mammalian Enamel: An Exploration of Decussation from the Micro- to the Macro-scale
Nanotechnology Enhanced Novel Bioresorbable Zn Alloy Implant for Short Bowel Syndrome Treatment
Negative Compressibility Architected Materials for Novel Cardiac Patches
Novel Zn-Fe-Si Alloy as Biodegradable Stent Material
On the Structure and Mechanical Properties of Aprismatic Enamel in Crocodilian Teeth
Strain Field Mining of Steady-state Tearing Fields in Thin Film, Heterogeneous Fiber Networks
Tapes: An Overlooked Biological Material Archetype
Tough Enlightenments From the Prayer Bead: Fracture-tolerant Endocarp of Elaeocarpus Ganitrus Seed (Rudraksha)
Understanding Heterogeneity in Bone Adaptation Following Exercise
Understanding the Role of Ridged Geometries in the Telson of the Mantis Shrimp

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