| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
C-3: Electrochemically Responsive Drug Delivery Systems with Ferrocene-containing Polyelectrolyte Complex Hydrogels for Controlled Release |
| Author(s) |
Victoria Messuri, Prakriti Dhungana, Asma Allababdeh, Cassidy Lyons, Kyle Duke, Bhargavi Mummareddy, Byung-Wook Park |
| On-Site Speaker (Planned) |
Victoria Messuri |
| Abstract Scope |
Chronic wounds are a major issue that millions of individuals are affected with annually, and the current treatment is costly. This study is to design a smart wound dressing made up of a polyelectrolyte complex hydrogel composed of ferrocene-branched chitosan with alginate to develop a novel drug delivery system. The ferrocene allows for an enhanced drug release kinetics so it can be responsive to the needs of the wound site. The Ninhydrin test, turbidity measurement, gel content, and swelling behavior were performed to characterize the electrochemical responsive hydrogel. The diffusion rates on a phantom skin surface were estimated with drug release kinetics of the model drugs. To design the smart wound dressing, custom-made flexible double layer electrodes containing the PEC hydrogel were fabricated, and then the in-vitro experiment was carried out. The developed wound dressing can be integrated with an enzyme-based biosensing element that detects biomarkers produced by the body. |