| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Tunable Nano-cerium Oxide for Radiation Mitigation |
| Author(s) |
Sudipta Seal, Melanie Coathup, Craig Neal, Fei Wei |
| On-Site Speaker (Planned) |
Sudipta Seal |
| Abstract Scope |
Engineered cerium oxide nanoparticles (CNPs) having mixed valences (Ce3+ and Ce4+) on their surface are known to scavenge excess reactive oxygen species (ROS), due to their redox active nature. We have shown that the injection of CNPs into a murine model exposed to ionizing radiation could lead to cytoprotection in tissues. Instances of DNA-double strand breaks as well as ROS concentration in tissue samples were also found to be significantly lower for specimens treated with CNPs. Our ongoing studies will present the role of CNP as radiosensitizer in tumor therapy. Another example will include in orthopedics application where increased bone loss and risk of fracture are the main challenges for cancer patients under ionizing radiation therapy. We have further investigated the effect of CNPs in reducing IR-induced functional damage in human bone marrow-derived mesenchymal stromal cells, further complemented by studying ROS levels, cellular proliferation, morphology, senescence, DNA damage, etc. |