| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Next Generation Models for Bone Metastasis of Cancer |
| Author(s) |
Kalpana S. Katti, Haneesh Jasuja, Farid Mohammadi Solaymani, Sharad V Jaswandkar, Jiha Kim, Anu Gaba, Dinesh R Katti |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
Emerging areas for bone biomaterials include therapies for bone metastasis and robust invitro models of bone metastasis of cancer. WHO reports 3.4M incidences of breast and prostate cancer and 1M deaths due to bone metastasis. We report novel nanoclay-based tissue-engineered scaffolds mimicking the bone-niche. In addition, we report design and fabrication of novel bioreactors simulating physiologically relevant fluid-flow enabled shear stresses. The bone-mimetic scaffolds are seeded with patient-derived breast and prostate cancer cells to create humanoid testbeds of bone-metastasis. The cancer cells influence osteogenesis, affecting prognosis for patients due to extensive skeletal failures. The Wnt/β-catenin signaling governs osteogenesis within the cancer proximity. Adhesion forces between cancer cells and bone are measured using an aspiration-based AFM. This initial attachment is crucial for bone metastasis and tumor progression. Morphological and ultrastructural changes to collagen fibrils are also observed on arrival of cancer. The novel testbed represents next-generation platform for investigation bone metastasis. |