|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
||Effects of Cell Sedimentation on Droplet Formation Process and Cell Distribution during Inkjet Printing of Cell-laden Bioink
||Heqi Xu, Md Shahriar, Jiachen Liu, Changxue Xu
|On-Site Speaker (Planned)
During inkjet-based bioprinting, the cell-laden bioink is ejected out from a nozzle dispenser to form cell-laden droplets, which are utilized as building blocks to fabricate 3D constructs based on a layer-by-layer mechanism. The bioink used for bioprinting is composed of biological materials and living cells. During the bioprinting process, the suspended cells in the bioink sediment due to the gravitational force, which may significantly affect the printing reliability as well as the shape fidelity of the fabricated 3D constructs. This study quantifies the effects of cell sedimentation on droplet formation process and cell distribution. Specifically, cell distribution includes cell distribution within the nozzle during the printing process and cell distribution within the formed microspheres after printing. The outcomes of this study will benefit the reliable printing process and facilitate homogeneous cell distribution during the fabrication of 3D cellular constructs using inkjet-based bioprinting.
||Biomaterials, Additive Manufacturing, Polymers