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Meeting 2022 TMS Annual Meeting & Exhibition
Symposium Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
Presentation Title 4D Printable Salicylic Acid Photopolymers for Sustained Drug-Releasing, Shape Memory Soft Tissue Scaffolds
Author(s) Andrew Christopher Weems
On-Site Speaker (Planned) Andrew Christopher Weems
Abstract Scope 3D printing pharmaceuticals offers long-term, sustained release of crucial drugs, but is limited by physical compounding and processing limitations. Here, salicylic acid is modified into a pro-drug form for incorporation in high concentrations, the role of different salicylic acid derivatives and of linker species is exploited using photoclick thiol-ene crosslinking in digital light processing (DLP) 3D printing to produce pro-drug scaffolds containing more than 50% salicylic acid. The scaffolds display tunable thermomechanical behaviors and elastomeric behaviors (elastic moduli of approximately 65 kPa), sustained release tuned through selection of the linker species with profiles ranging from 48 hours to several months, and cytocompatibility in 2D and 3D over a 2-week period using murine fibroblasts. Importantly, this material system is compatible with loading of other drugs for sequential, linear release profiles as a function composition, allowing for additional erosion control without compromising cytocompatibility, representing a distinct advance for 3D printing of pharmaceuticals.
Proceedings Inclusion? Planned:
Keywords Additive Manufacturing, Biomaterials, Polymers

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

4D Printable Salicylic Acid Photopolymers for Sustained Drug-Releasing, Shape Memory Soft Tissue Scaffolds
Acemannan loaded Mg-doped 3D printed multifunctional scaffolds: In vivo and in vitro biological Property evaluation
Additive manufacturing of natural materials as a multidisciplinary approach in Engineering Education
Biofilm Formation on Titanium Fabricated using Additive Manufacturing
Combining Traditional Electronics Packaging and NanoJet Aerosol Printing to Develop an Implantable High-density In-line Connector
Curcumin and Vitamin D3 enhances osteogenic and chemopreventive properties of 3D printed CaP bone scaffolds
Development and 3D Printing of a Bioabsorbable Composite Material for Orthopaedic Applications
Effect of Unit Cell Topology on the Mechanical Properties of Co-Cr-Mo Triply Periodic Minimal Surface Lattices Fabricated by Selective Laser Melting
Effects of Cell Sedimentation on Droplet Formation Process and Cell Distribution during Inkjet Printing of Cell-Laden Bioink
Effects of Topographic Parameters on a Micropillar Surface on Cell Migration and Morphology
Femto-second laser lithography of fluorescent 2D/3D nanostructures
Gingerol – Curcumin loaded Magnesium – Zinc Doped Calcium Phosphate Based Scaffolds and Coatings for Bone Tissue Engineering Applications
Influence of strut-size and cell-size variations on additively manufactured porous Ti6Al4V
Multifunctional Artificial Artery from Direct 3D Printing with Built-in Ferroelectricity and Tissue-Matching Modulus for Real-Time Sensing and Occlusion Monitoring
Prediction of Cell Viability in Dynamic Optical Projection Stereolithography-Based Bioprinting Using Machine Learning
Synthesis and Characterization of Hydroxyapatite from Solid Mineral for Dental and Orthopedic Applications

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