| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
NOW ON-DEMAND ONLY - 4D Printable Salicylic Acid Photopolymers for Sustained Drug-releasing, Shape Memory Soft Tissue Scaffolds |
| Author(s) |
Andrew Christopher Weems |
| On-Site Speaker (Planned) |
Andrew Christopher Weems |
| Abstract Scope |
3D printing pharmaceuticals offers long-term, sustained release of crucial drugs, but is limited by physical compounding and processing limitations. Here, salicylic acid is modified into a pro-drug form for incorporation in high concentrations, the role of different salicylic acid derivatives and of linker species is exploited using photoclick thiol-ene crosslinking in digital light processing (DLP) 3D printing to produce pro-drug scaffolds containing more than 50% salicylic acid. The scaffolds display tunable thermomechanical behaviors and elastomeric behaviors (elastic moduli of approximately 65 kPa), sustained release tuned through selection of the linker species with profiles ranging from 48 hours to several months, and cytocompatibility in 2D and 3D over a 2-week period using murine fibroblasts. Importantly, this material system is compatible with loading of other drugs for sequential, linear release profiles as a function composition, allowing for additional erosion control without compromising cytocompatibility, representing a distinct advance for 3D printing of pharmaceuticals. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Additive Manufacturing, Biomaterials, Polymers |