|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
||Curcumin and Vitamin D3 Enhances Osteogenic and Chemopreventive Properties of 3D Printed CaP Bone Scaffolds
||Yongdeok Jo, Susmita Bose
|On-Site Speaker (Planned)
Bone trauma, severe infection, and tumor ablations are causes of critical-sized bone defects which fail to heal on their own. This has reinforced the need for novel multifunctional bone graft to support bone regeneration. Additive manufacturing (AM) has shown advanced bone grafts attaining high accuracy and part complexity in bone defect repair applications. Multifunctional three-dimensional (3D) printing of calcium phosphate scaffolds with natural biomolecules presents a new trend in patient-matched implants to facilitate bone healing and chemoprevention. Curcumin has attracted much interest due to its wide range of therapeutic uses for chemoprevention and osteoporosis. Vitamin D3, which is needed to absorb calcium in the body, is an essential nutrient to maintain bone health. We have fabricated the 3D printed scaffolds with designed porosity, matching trabecular bone strength. Dual drug delivery of curcumin and vitamin D3 from the scaffolds induced apoptosis in osteosarcoma cells and enhanced in vitro osteoblast cell proliferation.
||Biomaterials, Ceramics, Additive Manufacturing