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Meeting 2022 TMS Annual Meeting & Exhibition
Symposium Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
Presentation Title Prediction of Cell Viability in Dynamic Optical Projection Stereolithography-Based Bioprinting Using Machine Learning
Author(s) Heqi Xu, Qingyang Liu, Changxue Xu, Dazhong Wu
On-Site Speaker (Planned) Heqi Xu
Abstract Scope Stereolithography (SLA)-based bioprinting is capable of fabricating 3D complicated structures such as vascular constructs with high printing accuracy and efficiency. However, maintaining high cell viability during SLA-based bioprinting process remains an unsolved challenge due to the cell damage induced by ultraviolet (UV) irradiation during the SLA printing process. Existing physics-based models have limitations on predicting cell viability with sufficient accuracy due to existing different complex pathways of cell damage. To address this issue, a data-driven predictive modeling approach using ensemble learning algorithm has been developed to predict cell viability under various experimental conditions in SLA-based bioprinting. A full factorial design of experiments has been conducted based on four critical process parameters including UV intensity, UV exposure time, polymer concentration, and layer thickness. The predictive model has been validated by the experimental results showing capability of predicting cell viability with high accuracy.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Additive Manufacturing, Machine Learning

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

4D Printable Salicylic Acid Photopolymers for Sustained Drug-Releasing, Shape Memory Soft Tissue Scaffolds
Acemannan loaded Mg-doped 3D printed multifunctional scaffolds: In vivo and in vitro biological Property evaluation
Additive manufacturing of natural materials as a multidisciplinary approach in Engineering Education
Biofilm Formation on Titanium Fabricated using Additive Manufacturing
Combining Traditional Electronics Packaging and NanoJet Aerosol Printing to Develop an Implantable High-density In-line Connector
Curcumin and Vitamin D3 enhances osteogenic and chemopreventive properties of 3D printed CaP bone scaffolds
Development and 3D Printing of a Bioabsorbable Composite Material for Orthopaedic Applications
Effect of Unit Cell Topology on the Mechanical Properties of Co-Cr-Mo Triply Periodic Minimal Surface Lattices Fabricated by Selective Laser Melting
Effects of Cell Sedimentation on Droplet Formation Process and Cell Distribution during Inkjet Printing of Cell-Laden Bioink
Effects of Topographic Parameters on a Micropillar Surface on Cell Migration and Morphology
Femto-second laser lithography of fluorescent 2D/3D nanostructures
Gingerol – Curcumin loaded Magnesium – Zinc Doped Calcium Phosphate Based Scaffolds and Coatings for Bone Tissue Engineering Applications
Influence of strut-size and cell-size variations on additively manufactured porous Ti6Al4V
Multifunctional Artificial Artery from Direct 3D Printing with Built-in Ferroelectricity and Tissue-Matching Modulus for Real-Time Sensing and Occlusion Monitoring
Prediction of Cell Viability in Dynamic Optical Projection Stereolithography-Based Bioprinting Using Machine Learning
Synthesis and Characterization of Hydroxyapatite from Solid Mineral for Dental and Orthopedic Applications

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