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Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Student Poster Contest + Rapid Fire
Presentation Title C-26: Nanoparticle-based drug delivery for the degradation of recalcitrant blood clots
Author(s) Hanyang Wang, Dante Disharoon, Shruti Raghunathan, Yolanda Fortenberry, Anirban Sen Gupta
On-Site Speaker (Planned) Hanyang Wang
Abstract Scope Arterial thrombosis, a leading cause of mortality, is characterized by pathological clots that restrict blood flow. Clots can be cleared using tissue plasminogen activator (tPA), but nearly half of arterial thrombi are recalcitrant to tPA degradation because they are stabilized by neutrophil extracellular traps (NETs), extrusions of DNA that reinforce clots structurally. Supplementing systemic tPA with deoxyribonuclease I (DNAse), which degrades NETs, has been shown to improve thrombolytic outcomes, but systemic tPA can cause iatrogenic hemorrhage. To mitigate this risk while maintaining thrombolytic potency, we developed clot-targeting tPA-loaded liposomal nanoparticles (tPA-LNP) that can be administered in a DNAse-rich solution. A thrombin-cleavable peptide was incorporated into tPA-LNP membranes such that thrombin, an enzyme upregulated in thrombosis, triggered release of the tPA payload. Additionally, tPA-LNP were decorated with a fibrin-binding peptide to localize their effects to a thrombus. tPA-LNP delivered in a DNAse-rich solution enhanced the lysis of tPA-recalcitrant clots in vitro.


C-13: Bioelectricity and Biomarker Acid Dual Targeting Fe3O4@Cu2-xS Nanoparticles for Photothermal Cancer Cell Killing
C-15: Blow Spinning of Polyvinyl Alcohol (PVA) and Polyvinylpyrrolidone (PVP) Scaffolds Embedded with Zinc Halloysite Nanotubules (HNTs)
C-16: Carvacrol and Curcumin: Potential Therapeutic Agents for Bone Defects Treatment
C-17: Effect of Patient-specific Blood Biomarkers on Nanoparticle-cell Interactions
C-18: Electrochemical Performance of EF-hand Peptide Conjugated with Tyrosine as an Aptamer for the Biosensing of Rare Earth Elements
C-19: Formulation of Biodegradable Polysaccharide Blend As Replacement of Single Use Plastic
C-20: Identifying Fouling Mechanisms of Polyproline II Helix Peptides on Gold Surface
C-21: Improvement and Validation of Computational Model of Biliary Stent Behavior
C-22: Investigation of Strontium-Copper-Dopped Sol-gel Bioglass for Soft-tissue Repair
C-23: Loading and Elution Efficiency of T2DA Loaded on Electrospun Chitosan Decanoic and Hexanoic Modified Membranes via Soaking Method
C-25: Mixed Brownian Alignment and Néel Rotations in Superparamagnetic Iron Oxide Nanoparticle Suspensions Driven by an AC Field
C-26: Nanoparticle-based drug delivery for the degradation of recalcitrant blood clots
C-27: Natural Medicinal Compounds Enhance Osteogenic and Antibacterial Properties of Calcium Phosphate-coatedTitanium
C-28: Raman and SEM-EDAX Analysis of Lithium and Gallium Doped Silicate and Borosilicate Sol Gel Bio Glasses for Anti Inflammatory Response
C-29: Synthesis and Characterization of Mesoporous β-Tricalcium Phosphate Powders Using Spray Drying for Orthopedic Applications
C-31: Evaluation of Hemostatic Properties of Procoagulant Synthetic Platelets
C-32: Detection of TIC-relevant Phenotypes with a Multichannel Miniaturized Dielectric Coagulometer Incorporating Bioactive Reagent-functionalized Electrodes

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