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Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Student Poster Contest + Rapid Fire
Presentation Title C-32: Detection of TIC-relevant Phenotypes with a Multichannel Miniaturized Dielectric Coagulometer Incorporating Bioactive Reagent-functionalized Electrodes
Author(s) Si Young Song, Michael Suster, Sina Pourang, Christopher Delianides, Dante Disharoon, Selvin Hernandez, Calvin Abonga, Hanif Alizadeh, Sanjay Ahuja, Matthew Neal, Anirban Sen Gupta, Pedram Mohseni
On-Site Speaker (Planned) Si Young Song
Abstract Scope Traumatic injury can lead to hemorrhage caused by trauma-induced coagulopathy (TIC), manifesting as a dysfunction in platelets, coagulation factors, or the fibrinolytic system, the three primary components of hemostasis. Timely identification of the dysregulated component is essential to guide resuscitation before exsanguination; however, current diagnostic tools are unsuited for point-of-injury/point-of-care (POI/POC) application, requiring that a patient be transported to a hospital before diagnosis can begin. To overcome this limitation, we developed a multi-channel miniaturized dielectric coagulometer for POI/POC deployment that uses bioactive material-coated electrodes to probe component-specific hemostatic function. Three types of electrodes were engineered: platelet-activating electrodes coated with thrombin receptor activating peptide 6 (TRAP-6), coagulation factor-activating electrodes coated with lipidated tissue factor (TF), and fibrinolysis-inhibiting lectrodes coated with aprotinin. These electrodes were individually sensitive to TIC-relevant coagulopathies recapitulated in vitro; when combined in our multi-channel coagulometer, they could be used to diagnose TIC with high specificity.


C-13: Bioelectricity and Biomarker Acid Dual Targeting Fe3O4@Cu2-xS Nanoparticles for Photothermal Cancer Cell Killing
C-15: Blow Spinning of Polyvinyl Alcohol (PVA) and Polyvinylpyrrolidone (PVP) Scaffolds Embedded with Zinc Halloysite Nanotubules (HNTs)
C-16: Carvacrol and Curcumin: Potential Therapeutic Agents for Bone Defects Treatment
C-17: Effect of Patient-specific Blood Biomarkers on Nanoparticle-cell Interactions
C-18: Electrochemical Performance of EF-hand Peptide Conjugated with Tyrosine as an Aptamer for the Biosensing of Rare Earth Elements
C-19: Formulation of Biodegradable Polysaccharide Blend As Replacement of Single Use Plastic
C-20: Identifying Fouling Mechanisms of Polyproline II Helix Peptides on Gold Surface
C-21: Improvement and Validation of Computational Model of Biliary Stent Behavior
C-22: Investigation of Strontium-Copper-Dopped Sol-gel Bioglass for Soft-tissue Repair
C-23: Loading and Elution Efficiency of T2DA Loaded on Electrospun Chitosan Decanoic and Hexanoic Modified Membranes via Soaking Method
C-25: Mixed Brownian Alignment and Néel Rotations in Superparamagnetic Iron Oxide Nanoparticle Suspensions Driven by an AC Field
C-26: Nanoparticle-based drug delivery for the degradation of recalcitrant blood clots
C-27: Natural Medicinal Compounds Enhance Osteogenic and Antibacterial Properties of Calcium Phosphate-coatedTitanium
C-28: Raman and SEM-EDAX Analysis of Lithium and Gallium Doped Silicate and Borosilicate Sol Gel Bio Glasses for Anti Inflammatory Response
C-29: Synthesis and Characterization of Mesoporous β-Tricalcium Phosphate Powders Using Spray Drying for Orthopedic Applications
C-31: Evaluation of Hemostatic Properties of Procoagulant Synthetic Platelets
C-32: Detection of TIC-relevant Phenotypes with a Multichannel Miniaturized Dielectric Coagulometer Incorporating Bioactive Reagent-functionalized Electrodes

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