|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Student Poster Contest + Rapid Fire
||C-16: Carvacrol and Curcumin: Potential Therapeutic Agents for Bone Defects Treatment
||Aditi Dahiya, Susmita Bose
|On-Site Speaker (Planned)
Phytochemicals have received wide attention due to their therapeutic potential in treating various diseases. Carvacrol and curcumin are compounds that show promising results in bone tissue engineering. This study investigates the cell-material interactions of carvacrol on calcium phosphate matrices. The findings demonstrate that carvacrol inhibits osteoclast cell viability and enhances the differentiation of human mesenchymal stem cells into osteoblasts. The bioactivity of carvacrol, when encapsulated in nanoparticles, increases its antibacterial efficacy and osteoblast cell viability while reducing osteosarcoma cell viability. The study also explores the synergistic effects of carvacrol and curcumin through nanoparticle encapsulation. The results indicate that the nanoparticle-treated scaffold promotes osteoblast cell activity and inhibits bacterial and osteosarcoma cell growth. These findings suggest the potential natural medicinal compounds within nano drug delivery vehicles on calcium phosphate scaffolds in developing personalized therapeutic implants for bone-related disorders.