|About this Abstract
|MS&T23: Materials Science & Technology
|Society for Biomaterials: Student Poster Contest + Rapid Fire
|C-17: Effect of Patient-specific Blood Biomarkers on Nanoparticle-cell Interactions
|Veronica Gabriela Contreras, Wilson Poon
|On-Site Speaker (Planned)
|Veronica Gabriela Contreras
Nanoparticles are a promising material class for bio-applications in drug delivery and vaccine development. Using gold nanoparticles of different sizes as a model nanomaterial system, we investigated how patients’ blood physiology and chemistry affected the biological response to bionanomaterials. When nanoparticles are injected into the body, biomolecules in the blood adsorb onto the nanoparticle surface to form a biomolecular corona that is specific to the patient’s unique blood composition, which dictates nanoparticle interaction with cells. Here we show that the abundance of certain proteins and lipids in patient blood changes the nanoparticle biomolecular corona. Furthermore, these adsorbed proteins and lipids then increase or decrease the in vitro cell uptake of nanoparticles. Our preliminary results suggest therefore that certain blood composition biomarkers can predict patient-specific biomaterial interactions. Studying how patient-specific blood biomarkers interact with biomaterials can help us rationally design personalized nanomaterials for therapeutic applications to improve their health.