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Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Student Poster Contest + Rapid Fire
Presentation Title C-31: Evaluation of Hemostatic Properties of Procoagulant Synthetic Platelets
Author(s) Jenny Lian, Norman Luc, Dante Disharoon PhD, Anirban Sen Gupta PhD
On-Site Speaker (Planned) Jenny Lian
Abstract Scope Trauma-induced non-compressible hemorrhage is a leading cause of mortality and morbidity in civilian and military settings across multiple age groups. While external compressible hemorrhage can be managed with topical dressings, internal non-compressible wounds are best treated with transfusion or blood products, i.e. red blood cells, plasma, and platelets. Unfortunately, platelets are limited by shelf life, storage, and portability issues, and blood products are subject to donor availability. We have previously developed a synthetic platelet-mimetic nanoparticle that mimics platelet adhesion, aggregation, and procoagulant functions to address the challenges of platelet transfusion. These synthetic platelets can expose phosphatidylserine on their surface upon exposure to plasmin to help colocalize coagulation factors and promote fibrin formation. We evaluated these synthetic platelets in dynamic settings to demonstrate their efficacy in fibrin generation. In conditions that recapitulate trauma-related pathophysiologies, the synthetic platelets increased fibrin generation, showing the potential for these particles in treating hemorrhage.


C-13: Bioelectricity and Biomarker Acid Dual Targeting Fe3O4@Cu2-xS Nanoparticles for Photothermal Cancer Cell Killing
C-15: Blow Spinning of Polyvinyl Alcohol (PVA) and Polyvinylpyrrolidone (PVP) Scaffolds Embedded with Zinc Halloysite Nanotubules (HNTs)
C-16: Carvacrol and Curcumin: Potential Therapeutic Agents for Bone Defects Treatment
C-17: Effect of Patient-specific Blood Biomarkers on Nanoparticle-cell Interactions
C-18: Electrochemical Performance of EF-hand Peptide Conjugated with Tyrosine as an Aptamer for the Biosensing of Rare Earth Elements
C-19: Formulation of Biodegradable Polysaccharide Blend As Replacement of Single Use Plastic
C-20: Identifying Fouling Mechanisms of Polyproline II Helix Peptides on Gold Surface
C-21: Improvement and Validation of Computational Model of Biliary Stent Behavior
C-22: Investigation of Strontium-Copper-Dopped Sol-gel Bioglass for Soft-tissue Repair
C-23: Loading and Elution Efficiency of T2DA Loaded on Electrospun Chitosan Decanoic and Hexanoic Modified Membranes via Soaking Method
C-25: Mixed Brownian Alignment and Néel Rotations in Superparamagnetic Iron Oxide Nanoparticle Suspensions Driven by an AC Field
C-26: Nanoparticle-based drug delivery for the degradation of recalcitrant blood clots
C-27: Natural Medicinal Compounds Enhance Osteogenic and Antibacterial Properties of Calcium Phosphate-coatedTitanium
C-28: Raman and SEM-EDAX Analysis of Lithium and Gallium Doped Silicate and Borosilicate Sol Gel Bio Glasses for Anti Inflammatory Response
C-29: Synthesis and Characterization of Mesoporous β-Tricalcium Phosphate Powders Using Spray Drying for Orthopedic Applications
C-31: Evaluation of Hemostatic Properties of Procoagulant Synthetic Platelets
C-32: Detection of TIC-relevant Phenotypes with a Multichannel Miniaturized Dielectric Coagulometer Incorporating Bioactive Reagent-functionalized Electrodes

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