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Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Biomaterial Applications
Presentation Title Crosslinked Microfluidic Protein-based Microgels for Cardiac Tissue Engineering
Author(s) Chao Liu, Douglas Wu, Valinteshley Pierre, Yiwen Gao, Sam Senyo
On-Site Speaker (Planned) Chao Liu
Abstract Scope The heart's decellularized extracellular matrix (dECM) is a promising therapeutic biomaterial that can improve cardiac function, reduce fibrosis, and promote cell proliferation in infarcted heart models. Injecting dECM hydrogel in its sol state has demonstrated encouraging outcomes, but the retention at the injection site is limited, and there is a burst release of biologics. Electrospray dECM microparticles have shown extended stability in tissue, maintaining controlled protein release while preserving the regenerative effects. However, particle polydispersity and batch-to-batch variability have been challenging. Using an in-house designed microfluidic droplet generator, we investigated the parameters that determine droplet diameter by adjusting driving pressure and microfluidic dimensions. Optimization studies revealed that increased nozzle diameter and input pressure independently increased droplet diameter. We will evaluate the microfluidic generation and UV crosslinking of dECM microparticles, and investigate their in vitro and in vivo bioactivity, releasing profile, and regenerative effects in future studies.


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Cell Encapsulation and Delivery in Tissue Engineering Using Bijels-derived Bicontinuous Structures
Crosslinked Microfluidic Protein-based Microgels for Cardiac Tissue Engineering
Double-Crosslinking-Double-Network Injectable Hydrogels Design for Wound Treatment
Electroadhesion of Hydrogels to Tissues: A Simple Way to Perform Suture-less Surgical Repair
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Molecular Weight of Polyethylenime Dependent Formation of Gold Nanoparticles and Their Biomedical Application
Multifunctional Lanthanide-doped Nanomaterials for Imaging and Sensing
Novel Biocompatible Nanoparticle Emulsion for Sustained Therapeutic Drug Delivery
Oxidative Stress Responsive Nanoparticles for Sustained Protein Delivery in Treatment of Ocular Degeneration
Selective Cellular Interaction of PEI Functionalized Silver Nanoparticles with Pathogenic Microorganisms
Structural and Some Mechanical Properties of Parquetina Nigrescens Pod Nanoparticles Reinforced Polylactic Acid Composites
Therapeutic Potential of Mesoporous Nanoparticles Loaded Cardiac Patch for Mending Broken Hearts
UV Crosslinking for Micropatterning Decellularized Heart Matrix

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