ProgramMaster Logo
Conference Tools for MS&T23: Materials Science & Technology
Register as a New User
Submit An Abstract
Propose A Symposium
Presenter/Author Tools
Organizer/Editor Tools
About this Abstract
Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Biomaterial Applications
Presentation Title UV Crosslinking for Micropatterning Decellularized Heart Matrix
Author(s) Valinteshley Pierre, Chao Liu, Elif Ertugral, Douglas H Wu, Chandrasekhar Kothapalli, Samuel Senyo
On-Site Speaker (Planned) Valinteshley Pierre
Abstract Scope Decellularized heart matrix (DHM) therapy is a tissue engineering strategy to repair cell death and tissue disorganization that follows ischemic heart injury. DHM is a tissue-derived hydrogel that shows promise as a vehicle for stem cell transplantation. Natural biomaterials such as DHM exhibit weak mechanical integrity. To address this limitation, we designed crosslinkable DHM for soft lithography patterning to organize donor cells. The formulations were achieved by chemically modifying DHM with methacryloyl functional groups (DHM-MA) to enable crosslinking via UV. We first characterized DHM-MA degree of methacrylation, crosslinking, and micropatterning integrity. Different formulations were evaluated by atomic force microscopy, spectroscopy, microscopy, and cell culture fidelity. We show modulation of stiffness with different formulations and UV time. Cells cultured on DHM-MA attach and remain viable. The current evidence demonstrates that minimum topographical features can be lowered with higher aspect ratios dependent on crosslinking density.


Bioinspired Adhesives for Surgical Glue Applications
C-10: A Study on the Stress Analysis of the Vertebral Body According to the Posture of Patients Undergoing Lumbar Bone Implant Surgery
C-11: Lens Epithelial Cell Response to Polymer Surface Chemistry, Mechanical Properties and Micropatterns
Cell Encapsulation and Delivery in Tissue Engineering Using Bijels-derived Bicontinuous Structures
Crosslinked Microfluidic Protein-based Microgels for Cardiac Tissue Engineering
Double-Crosslinking-Double-Network Injectable Hydrogels Design for Wound Treatment
Electroadhesion of Hydrogels to Tissues: A Simple Way to Perform Suture-less Surgical Repair
Eumelanin: A Promising Material for Bio-based Electronics
Magnetoactive Hydrogels to Fabricate Tissue Patterns
Molecular Weight of Polyethylenime Dependent Formation of Gold Nanoparticles and Their Biomedical Application
Multifunctional Lanthanide-doped Nanomaterials for Imaging and Sensing
Novel Biocompatible Nanoparticle Emulsion for Sustained Therapeutic Drug Delivery
Oxidative Stress Responsive Nanoparticles for Sustained Protein Delivery in Treatment of Ocular Degeneration
Selective Cellular Interaction of PEI Functionalized Silver Nanoparticles with Pathogenic Microorganisms
Structural and Some Mechanical Properties of Parquetina Nigrescens Pod Nanoparticles Reinforced Polylactic Acid Composites
Therapeutic Potential of Mesoporous Nanoparticles Loaded Cardiac Patch for Mending Broken Hearts
UV Crosslinking for Micropatterning Decellularized Heart Matrix

Questions about ProgramMaster? Contact