A successful biomedical adhesive must be biocompatible, set in a wet environment, match the mechanical properties of the surrounding tissue, and have proper adhesive and cohesive properties. Current technologies do not meet these needs. We developed bioinspired protein-based adhesives that combine adhesion from DOPA residues found in mussel adhesive proteins with the mechanical properties of elastin, which can also coacervate in response to the environment. We demonstrated that these proteins are cytocompatible, provide the strongest bonds of any rationally designed protein when used completely underwater, and can be easily applied underwater because they coacervate in physiological conditions. We have also investigated different formulations and crosslinking chemistries in physiologically relevant environments by using pig skin substrates and curing in a warm, humid environment. Recently, we have developed a sealant based on a corn protein that seals a variety of tissues.