|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Biomaterial Applications
||C-11: Lens Epithelial Cell Response to Polymer Surface Chemistry, Mechanical Properties and Micropatterns
||Hamid Hamedi, Katelyn Swindle-Reilly, Raima Puri, Heather Chandler, Derek Hansford, Hanna Cho, Michael Lee
|On-Site Speaker (Planned)
Cataract is the loss of human lens transparency due to opacification of the lens. While surgical extraction of the lens and intraocular lens (IOL) implantation is an effective technique to treat cataract, it is reported that 2-3 years after cataract surgery, a significant proportion of cataract patients experience impaired vision due to posterior capsule opacification (PCO). It is reported different IOLs have different PCO incidents and revealed the effect of material and IOL design on the cataract reoccurrence. Most IOLs contain PMMA or other polymers, and the mechanical properties of the implanted PMMA are very different from the soft, viscoelastic native lens tissue. Our hypothesis is that soft and viscoelastic polymers may decrease EMT. Micropatterning could also help to limit LEC migration onto implanted IOLs. Human lens cells response to the polymer surface chemistry, stiffness and micropatterned surface were evaluated in this study.