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Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Biomaterial Applications
Presentation Title C-11: Lens Epithelial Cell Response to Polymer Surface Chemistry, Mechanical Properties and Micropatterns
Author(s) Hamid Hamedi, Katelyn Swindle-Reilly, Raima Puri, Heather Chandler, Derek Hansford, Hanna Cho, Michael Lee
On-Site Speaker (Planned) Hamid Hamedi
Abstract Scope Cataract is the loss of human lens transparency due to opacification of the lens. While surgical extraction of the lens and intraocular lens (IOL) implantation is an effective technique to treat cataract, it is reported that 2-3 years after cataract surgery, a significant proportion of cataract patients experience impaired vision due to posterior capsule opacification (PCO). It is reported different IOLs have different PCO incidents and revealed the effect of material and IOL design on the cataract reoccurrence. Most IOLs contain PMMA or other polymers, and the mechanical properties of the implanted PMMA are very different from the soft, viscoelastic native lens tissue. Our hypothesis is that soft and viscoelastic polymers may decrease EMT. Micropatterning could also help to limit LEC migration onto implanted IOLs. Human lens cells response to the polymer surface chemistry, stiffness and micropatterned surface were evaluated in this study.


Bioinspired Adhesives for Surgical Glue Applications
C-10: A Study on the Stress Analysis of the Vertebral Body According to the Posture of Patients Undergoing Lumbar Bone Implant Surgery
C-11: Lens Epithelial Cell Response to Polymer Surface Chemistry, Mechanical Properties and Micropatterns
Cell Encapsulation and Delivery in Tissue Engineering Using Bijels-derived Bicontinuous Structures
Crosslinked Microfluidic Protein-based Microgels for Cardiac Tissue Engineering
Double-Crosslinking-Double-Network Injectable Hydrogels Design for Wound Treatment
Electroadhesion of Hydrogels to Tissues: A Simple Way to Perform Suture-less Surgical Repair
Eumelanin: A Promising Material for Bio-based Electronics
Magnetoactive Hydrogels to Fabricate Tissue Patterns
Molecular Weight of Polyethylenime Dependent Formation of Gold Nanoparticles and Their Biomedical Application
Multifunctional Lanthanide-doped Nanomaterials for Imaging and Sensing
Novel Biocompatible Nanoparticle Emulsion for Sustained Therapeutic Drug Delivery
Oxidative Stress Responsive Nanoparticles for Sustained Protein Delivery in Treatment of Ocular Degeneration
Selective Cellular Interaction of PEI Functionalized Silver Nanoparticles with Pathogenic Microorganisms
Structural and Some Mechanical Properties of Parquetina Nigrescens Pod Nanoparticles Reinforced Polylactic Acid Composites
Therapeutic Potential of Mesoporous Nanoparticles Loaded Cardiac Patch for Mending Broken Hearts
UV Crosslinking for Micropatterning Decellularized Heart Matrix

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