|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Biomaterial Applications
||Therapeutic Potential of Mesoporous Nanoparticles Loaded Cardiac Patch for Mending Broken Hearts
||Syed Baseeruddin Alvi, Muhamad Mergaye, Divya Sridharan, Abbey Forehand, Niki Blackstone, Uzair Ahmed, Xianyao Xu, Heather Powell, Mahmood Khan
|On-Site Speaker (Planned)
||Syed Baseeruddin Alvi
Introduction: Acute myocardial ischemia results in a cascade of downstream inflammatory responses causing scar formation which further exacerbates myocardial functioning.
Hypothesis: Localized delivery of growth factors loaded cardiac patch onto the damaged heart will improve angiogenesis and improve cardiac function.
Methods and Results: In the current study, a composite nanofiber cardiac patch (CNFP) was fabricated by electrospinning gelatin and polycaprolactone (200 Ám) and studding it with mesoporous polydopamine nanoparticles (200-250 nm) loaded with basic Fibroblast Growth Factor (bFGF). The CNFPs were tested for bFGF release in vitro. The in vivo efficacy of CNFPs was tested by suturing them epicaredially onto the infarcted hearts induced by left anterior descending (LAD) coronary artery ligation in mice. CNFPs significantly preserved the cardiac function by improving ejection fraction and strain, when compared to the control (untreated) group as assessed by echocardiography.
Conclusion: CNFPs loaded with bFGF promote localized angiogenesis and improve cardiac function.