|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Biomaterial Applications
||Cell Encapsulation and Delivery in Tissue Engineering Using Bijels-derived Bicontinuous Structures
||Haoran Sun, William W. Lu, Min Wang
|On-Site Speaker (Planned)
Bicontinuous interfacially jammed emulsion gels (“bijels”) are soft matters and contain two interpenetrating continuous liquid phases. They can serve as templates to produce bijels-derived bicontinuous structures with interconnected channels. Tissue engineering employs cell encapsulation and delivery strategies, and channels in bijels-derived structures may provide suitable space for cell encapsulation, proliferation and migration. In this study, bijels-derived structures with large channel sizes were made first using bijels that were fabricated via a phase inversion process as the template. To encapsulate rat bone marrow-derived mesenchymal stem cells (MSCs) in these structures, MSC suspensions were mixed with alginate solution, and mixed solutions were used to infiltrate into channels in bijels-derived structures. Results showed that MSC-incorporated hybrid structures were good cell delivery vehicles. MSCs could migrate out from interconnected channels. They could proliferate well in and on hybrid structures after cell delivery. Cell release could be controlled by crosslinking degree of the alginate phase.