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Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
Presentation Title Cancer Cell-substrate Microenvironment Crosstalk in Metastasis Progression in Tissue Engineering Scaffolds
Author(s) Dinesh Katti, Sharad V Jaswandkar, Hanmant Gaikwad, Kalpana Katti
On-Site Speaker (Planned) Dinesh Katti
Abstract Scope The bone microenvironment and mechanical cues like fluid flow influence metastasis. The presence of extracellular minerals modulates membrane proteins' conformation, resulting in signal transduction within the cells. We report extensive computational studies in tandem with experiments on invitro testbeds of cancer metastasis to the bone using patient-derived cell lines of breast and prostate cancer in bioreactors. We evaluate the mechanics of both internal moieties (actins) as well as external (integrins) that influence the mechanics of cells. Actin filaments polymerization and depolymerization are key to the cell-cell adhesion observed in tumor formation. Our modeling studies elucidate detailed mechanisms of the cofilin decorations that influence the polymerization and depolymerization of the actins on loading. Our investigations on the cellular adhesion protein αvβ3 integrin and the cytoskeletal protein actin provide insight into their mechanical response, critical to cellular function, and provide an insight into stem cell differentiation leading to bone tissue regeneration.


Antimicrobial Coatings Based on Antimicrobial Peptides for Biomedical Applications
Antimicrobial Surface Engineering: Towards Infection Resistant Implants
C-9: Dual Function of Plasma Nanocoatings in Cardiovascular Stent Applications
Cancer Cell-substrate Microenvironment Crosstalk in Metastasis Progression in Tissue Engineering Scaffolds
Development of Composite Si3N4-PEKK Biomaterial Coatings to Improve Ti6Al4V’s Antibacterial Properties and Osteogenic Response
Surface Modification of MgZnCa Alloys Using Plasma Electrolytic Oxidation to Assess Corrosion Resistance and Biocompatibility
Surface Modification Strategies for Inhibiting Biofilm Formation on Biomaterials
Tailoring of Antimicrobial Surface Through Nanostructured Ceramic Coatings
Topographical Effect on Hs27 Fibroblast Response

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