|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
||C-9: Dual Function of Plasma Nanocoatings in Cardiovascular Stent Applications
||Thithuha Phan, Meng Chen, Qingsong Yu, John Jones
|On-Site Speaker (Planned)
In coronary stenting procedures, in-stent restenosis and thrombosis pose ongoing challenges. This study aimed to assess the effectiveness of trimethylsilane (TMS) plasma nanocoatings, specifically modified with NH3/O2 (2:1 molar ratio) plasma post-treatment (TMS+NH3/O2 nanocoatings), on cobalt chromium (CoCr) alloy L605. X-ray photoelectron spectroscopy (XPS) analysis demonstrated the enduring chemical stability of these nanocoatings over a 2-year aging period.
To evaluate their in vitro biological responses, we conducted experiments involving porcine coronary artery endothelial cells (PCAECs) and smooth muscle cells (PCASMCs). Co-culture results indicated a significant preference for PCAEC growth, with comparable migration observed between uncoated L605 and TMS+NH3/O2 nanocoatings. Conversely, PCASMC migration was markedly reduced (approximately 8.5-fold) on TMS+NH3/O2 nanocoating surfaces.
Platelet adhesion tests, using porcine whole blood, showed diminished adhered platelets, reduced clotting attachment, and decreased platelet activation on TMS+NH3/O2 nanocoatings. These findings underscore the potential of TMS+NH3/O2 nanocoatings to mitigate both restenosis and thrombosis in coronary stent applications.