|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
||Antimicrobial Surface Engineering: Towards Infection Resistant Implants
||Annabel Braem, Merve Kübra Aktan, Nur Hidayatul Nazirah Kamarudin, Marie Van der Gucht, Naiera Zayed, Rob Lavigne, Wim Teughels
|On-Site Speaker (Planned)
Medical device-associated infections compromise the longevity of prosthetic implants. Microbial biofilms, which form on the implant surface, are among the main causes of recalcitrance of such peri-implant infections. Therefore, there is a growing interest in the local delivery of antimicrobial agents at the implant surface to discourage microbial colonization and biofilm formation. Delivery strategies include controlled release from drug-eluting carriers and permanent attachment (immobilization) at the implant surface. Both concepts offer interesting advantages, but practical implementations still need to be improved with respect to mechanical stability of the materials and spatial and temporal control over the drug concentration. We present several approaches addressing the currently experienced needs in implant-based drug delivery which will allow establishing more therapeutically effective infection prevention and treatment in the future.