ProgramMaster Logo
Conference Tools for MS&T23: Materials Science & Technology
Register as a New User
Submit An Abstract
Propose A Symposium
Presenter/Author Tools
Organizer/Editor Tools
About this Abstract
Meeting MS&T23: Materials Science & Technology
Symposium Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
Presentation Title Surface Modification Strategies for Inhibiting Biofilm Formation on Biomaterials
Author(s) Christopher Siedlecki, Alyssa Ochetto, Chen Chen, Dongxiao Sun, Asma Khursheed, Harry Allcock, Lichong Xu
On-Site Speaker (Planned) Christopher Siedlecki
Abstract Scope Biomaterial centered infections remain an impediment to the use of implantable medical devices. These infections arise from initial adhesion of bacteria to a surface, followed by proliferation and maturation into biofilms. Mature biofilms exude an extracellular covering referred to as extracellular polymeric substances (EPS) which protects the bacterial community from antibiotics as well as normal immune responses. We have developed methods to affect both initial attachment of bacteria as well as the subsequent maturation. In recent work, we identified small molecules that interfere with intracellular signaling molecules in bacteria. Using nitric oxide and small molecules derivates of 4-arylazo-3,5-diamino-1H-pyrazole as inhibitors of intracellular nucleotide signaling molecules, biofilms were largely eradicated from the surface with orders of magnitude reductions in viable bacteria. Further, we show that these molecules and disruption of the biofilm allows for increased efficacy of antibiotics, with 2 ug/ml ciprofloxacin generating 3 orders of magnitude reductions in viable bacteria.


Antimicrobial Coatings Based on Antimicrobial Peptides for Biomedical Applications
Antimicrobial Surface Engineering: Towards Infection Resistant Implants
C-9: Dual Function of Plasma Nanocoatings in Cardiovascular Stent Applications
Cancer Cell-substrate Microenvironment Crosstalk in Metastasis Progression in Tissue Engineering Scaffolds
Development of Composite Si3N4-PEKK Biomaterial Coatings to Improve Ti6Al4V’s Antibacterial Properties and Osteogenic Response
Surface Modification of MgZnCa Alloys Using Plasma Electrolytic Oxidation to Assess Corrosion Resistance and Biocompatibility
Surface Modification Strategies for Inhibiting Biofilm Formation on Biomaterials
Tailoring of Antimicrobial Surface Through Nanostructured Ceramic Coatings
Topographical Effect on Hs27 Fibroblast Response

Questions about ProgramMaster? Contact