|About this Abstract
||MS&T23: Materials Science & Technology
||Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
||Development of Composite Si3N4-PEKK Biomaterial Coatings to Improve Ti6Al4V’s Antibacterial Properties and Osteogenic Response
||Jackson Hendry, Tony Decarmine, James Porteus, Douglas Hoxworth, B. Sonny Bal, Ryan Bock, Thomas Webster
|On-Site Speaker (Planned)
Ti6Al4V is a commonly-used implant bioinert material with a well-established safety record. However, bio inertness prevents Ti6Al4V devices from actively participating in tissue integration or resisting bacterial biofilm formation.
Silicon nitride (Si3N4), a high surface energy biomaterial currently used in spinal fusion devices, has established antibacterial and osteogenic performance. Polyetherketoneketone (PEKK) has also exhibited these properties when 3D-printed with engineered surface texture to enhance its surface energy.
Sintered beta-Si3N4 particles were suspended in a PEKK casting solution and applied to Ti6Al4V substrates by dip coating. The resultant composite coatings were evaluated to determine their physicochemical properties, protein adsorption, cytotoxicity, osteoblast adhesion and mineralization, and resistance to colonization by common orthopedic bacteria.
The evaluation revealed an adherent composite coating with increased surface energy, protein adsorption, resistance to biofilm formation, and enhanced osteoblast mineralization. This novel Si3N4-PEKK coating represents a potential new pathway to functionalize inert implantable devices.