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Meeting 2022 TMS Annual Meeting & Exhibition
Symposium Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
Presentation Title Dynamic Vessel-on-a-chip Model: Bringing Bio-relevance to In Vitro Evaluation of Quantum Dots
Author(s) Hagar I. Labouta
On-Site Speaker (Planned) Hagar I. Labouta
Abstract Scope Microfluidics, manipulation of fluids at the sub-millimetre scale, has given rise to platforms for controlled synthesis of nanomaterials as well as to biomimetic systems called organ-on-a-chip to evaluate nanoparticles under conditions mimicking in vivo scenarios. My talk will focus on our research on synthesizing nanoparticles under controlled flow conditions and examining their interaction with cells exposed to shear stress due to flow. We have developed a vessel-on-a-chip model using vascular endothelial cells (HUVEC) subjected to shear stress within the physiological range, 1 dyne/cm2. Using this model, we examined the effect of wall shear stress on the interaction of quantum dots with the endothelium in regards to cell viability, cell internalization of quantum dots, as well as their effect on the cell transcriptome using microarray analysis. The results of this work will direct future studies towards the use of in vitro approaches for improving in vitro-in vivo correlation.
Proceedings Inclusion? Planned:
Keywords Nanotechnology, Biomaterials,

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

2D Materials for Lithium Batteries
3D Printing Bionic Devices
Architecting 3D Lithium-ion Batteries
Controlled Synthesis of Gas Sensing Composite Metal/Metal Oxide Graphene-based Nanofibers
Crumpling and Assembling of 1D/2D Nanomaterials into 3D Functional Structures
Dynamic Vessel-on-a-chip Model: Bringing Bio-relevance to In Vitro Evaluation of Quantum Dots
Effects of Graphene Surface Interaction on Water-ice Phase Change
Electrical Detection and Characterization of Individual Molecules with Single Nanometer-scale Pores
Electrochemical Behaviors of Two-dimensional Materials for Energy Applications
Electrochemical Imaging of Precisely Defined Redox and Reactive Nanomaterials
Electron Transport in Plasmonic Nanocomposites
Engineered Nanoclays in Bone Tissue Engineering and Bone Metastasis of Cancer
Exciton Transport in Strained Two-dimensional Semiconductors
Extinction Properties of Singular Plasmonic Nanoparticles
Fabrication of Hexagonal Diamond by Aqueous Solution-based Electrochemistry
Facile Synthesis of Novel Quaternary Zn-Cu-In-S/ZnS QDs- mTHPP Porphyrin Conjugate and Its Photodynamic Therapy of Cancer and Antibacterial Activities
Freeze Casting of Graphene Aerogel Structures with Unidirectional Pores
H-10: The Interaction Dynamics and Binding Strength of Proteins on Gold Nanoparticles
H-9: Strain-induced Reversible Phase Transitions in 2D Transition Metal Dichalcogenides
Harnessing Microstructures for Tunable Interference Color
Hydrogen Sensing Using Novel Core-shell Plasmonic Nanoparticles
In-situ Investigation of the Interface Formation between Si-terminated Diamond and a Nb2O5 Electron Acceptor Layer for Electronic Applications
In Situ Chemo-mechanical Characterization of the Formation and Oxidation of Redox Reaction Products at Nanoscale For Li-O2 Batteries
In Situ Spectroscopic Characterization of the Electrode-electrolyte Interphase
Intrinsic Fatigue of Graphene and Molybdenum Disulfide
Investigation of the Capturing Mechanism of Aerosols on Functional Polymeric Fiber Matrix
Joining Graphene-modified Textile Fiber Sensors via Nanosolder Melting and Interconnection
LED Assisted Synthesis and Excitation of Silver Nanoparticles for Plasmon-enhanced Antibacterial Effects
Machine Learning Analysis of Spectral Data Using Bacteria for Signal Amplification
Mechanics Design in Cellulose-enabled High-performance Functional Materials
Mickey Mouse on NanoCaffeine
Multi-scale Numerical Modelling of Nanoparticle Transport across the Placental Barrier on Placenta-on-a-chip Physical Model
Nanoscale Effects on Intercalation-induced Phase Transitions in 2D Materials
Nanoscale Frictional Behavior of Two-dimensional Materials
Nanostructured Materials: A Review on Its Application in Water Treatment
NOW ON-DEMAND ONLY – H-8: Hydrothermal Synthesis of ZnO Nanorod Arrays for Gas Sensing
NOW ON-DEMAND ONLY - MOF-derived Metal Oxide Composites for High Performance Energy Storage
NOW ON-DEMAND ONLY – Salt Treatment to Purify Carbon Nanotube Sheets Produced via the Floating Catalyst CVD Method
Optically Active Nanoparticles in Protein Corona Studies
Photoabsorbers with 2D Layered Perovskites for Bendable Optoelectronics and Solar Cells
Plasmonic Approaches to Biology and Medicine
Plasmonic Nanoparticles for Sensing, Drug Delivery and Photothermal Therapy of Cancer
Porous Assemblies of 2-D MnO2 Nanosheets and Their Conversion to 1-D Tunnel Structures
Processing of Nanocrystalline Diamond Coatings for Biomedical Applications
Rapid and Scalable Fabrication of Hierarchical Multiscale Nanocomposite Films for Bone Tissue Repair and Infection Control
Real-time Observations of Chemo-mechanical Behaviors of Si-based Anodes for Advanced Lithium-ion Batteries
Reticulated Structure of Sulfur/Nitrogen-doped Graphene Oxide for High Specific Energy Lithium/Sulfur cells
Second NIR-absorbing Gelatin Stabilized Gold Nanorods with High Media and Photothermal Stability for Photothermal Cancer Therapy
Skin-interfaced Wearable Biosensors
Solid-State Transformation of 0D Metal Nanoparticles to Anisotropic 2D Morphologies
Spatial Control of Laser Induced Graphene Morphology on Flexible Substrates
Strain-tunable Optoelectronic Response of Crumpled Graphene/Organic Semiconductor Heterostructure
Structural Evolution and Electrical Conductivity of Polymer Derived Ceramics
Suspended Graphene/PEDOT:PSS Channel for H2 Gas Sensing Fabricated Using Direct-write Functional Fibers
The Influence of Magnetic Moment on Chemical Activity for Design of Hierarchical Electrochemical Systems
The Scaling of Low-temperature Ferroelectric Hf0.5Zr0.5O2 Thin Films Using Anhydrous H2O2
Thermal Conductivity Enhancement of PEO/PEDOT:PSS Composite Nanofiber
Tuning the Rapid Thermochemical Pretreatment of Alumina-supported Iron Catalyst to Improve Catalytic Lifetime in Chemical Vapor Deposition of Carbon Nanotubes
Wafer-scale Epitaxial Growth of 2D Transition Metal Dichalcogenides
Water-driven CH3NH3PbBr3 Nanocrystals
“Smart” Biodegradable Polymer at Nano and Micro Scales for Medical Applications

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