|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
||Multi-scale Numerical Modelling of Nanoparticle Transport across the Placental Barrier on Placenta-on-a-chip Physical Model
||Hongwei Liu, Anisa Khan, Moustafa Ali, Hagar Labouta, Pooneh Maghoul
|On-Site Speaker (Planned)
The rapid development of nanotechnologies offers unique advantages in nanomedical therapies during pregnancy. The ability to control the beneficial effects of nanoparticle and to avoid toxicity during treatment requires in-depth understanding of the mechanism of nanoparticle transport across the placental barrier. In this paper, a novel placenta-on-a-chip model is designed to mimic the structure of placental barrier with an upper channel representing maternal side and a lower channel representing fetal side. A multi-scale finite element model is developed to study the effect of nanoparticle size, nanoparticle concentration, flow rate, and diffusion of placental barrier on the transport of nanoparticle across the placental barrier. The proposed multi-scale model can be used to study the transport of nanoparticle under various conditions so that preliminary recommendations can be given to reduce the risk of nanoparticle-related toxicity during pregnancy treatment.
||Nanotechnology, Modeling and Simulation, Biomaterials