|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Advanced Functional and Structural Thin Films and Coatings
||Silicone Breast Implants: Grafting of a Bioactive Polymer to Improve the Bio-integration
||Mylan Lam, Vincent Humblot, Romain Vayron, Véronique Migonney, Celine Falentin-Daudre
|On-Site Speaker (Planned)
Silicone breast implant (BI) issues have raised many concerns these past years. Part of the top 10 most implantable biomedical devices, BIs are widely used for aesthetic and reconstructive surgeries. However, as with any devices, BIs are subjected to healthcare-associated infections as the development of capsular contractures mostly or, more rarely, the apparition of large cell anaplasic lymphoma, a cancer-related to breast prosthesis. The grafting of bioactive polymers has been actively demonstrated to improve surfaces’ bio-integration by conferring them an antibacterial property and improving biocompatibility. In the scientific literature, numerous strategies are reported to overcome bacterial biofilms and improve the surface’s biocompatibility by surface modifications. Our team has recently achieved a simple way to graft the poly(styrene sodium sulfonate) directly on silicone breast implants outer shell only using UV irradiation with a grafting “from” strategy. Characterization methods as SEM, XPS, AFM, ATR-FTIR, colorimetric assay, and WCA confirmed the grafting.
||Biomaterials, Polymers, Surface Modification and Coatings