| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials 2024
|
| Presentation Title |
Synthesis of Graphene Oxide-Gold Nanorods Nanocomposite-Porphyrin Conjugate for Improved Dual Cancer Phototherapy Performance |
| Author(s) |
Thabang Calvin Lebepe, Oluwatobi Samuel Oluwafemi |
| On-Site Speaker (Planned) |
Thabang Calvin Lebepe |
| Abstract Scope |
The Cancer modality rate has been increasing, and conventional cancer treatments are known for many side effects. Therefore, finding a new therapeutic agent or modifying the existing therapeutic agents is imperative for better performance and efficiency. Herein, a phototherapeutic agent is reported that would be useful for synergetic photothermal and photodynamic therapy. The agent consists of TMePyP (5,10,15,20-tetrakis(N-methylpyridinium-3-yl)porphyrin) and gold nanorods (AuNRs) anchored on graphene oxide (GO) sheet. Initially, the GO and AuNRs were synthesised using Hummer’s method and seed-mediated method, respectively. TMePyP and AuNRs were anchored on GO to form GO@AuNRs-TMePyP nanocomposite via electrostatic and π-π stacking. The nanocomposite was stable in different mediums and, on irradiation, produced high heat than AuNRs, with high photothermal efficiency. In addition, the nanocomposite produced higher singlet oxygen than TMePyP with high biocompatibility without light. These results indicated that the as-synthesised nanocomposite as a promising dual photodynamic and photothermal agent for cancer therapy. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Composites, Characterization, Surface Modification and Coatings |