| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
H-7: Broad Spectrum, Potent and Durable Ceria Nanoparticles Inactivate RNA Virus Infectivity by Targeting Virion Surfaces and Disrupting Virus-receptor Interactions |
| Author(s) |
Candace R. Fox, Kritika Kedarinath, Craig J Neal, Elayaraja Kolanthai, Udit Kumar, Christina Drake, Sudipta Seal, Griffith D. Parks |
| On-Site Speaker (Planned) |
Candace R. Fox |
| Abstract Scope |
There is intense interest in developing long-lasting, potent and broad-spectrum antiviral disinfectants. Ceria nanoparticles (CNPs) can undergo surface redox reactions (Ce3+ ↔ Ce4+) to generate ROS. We previously reported potent inactivation of enveloped and non-enveloped RNA viruses by silver-modified CNPs, AgCNP1 and AgCNP2. Here, treatment of human respiratory viruses, coronavirus OC43 and parainfluenza virus type 5 (PIV5) with AgCNP1 and 2, respectively, prevented virus interactions with host cell receptors and resulted in virion aggregation. Consistent with regenerative properties of CNPs, glass-applied AgCNPs inactivated a wide range of structurally diverse viruses, including enveloped (OC43, SARS-CoV-2, and PIV5) and non-enveloped RNA viruses (RV14 and feline calicivirus; FCV). Remarkably, a single application of AgCNP1 and 2 potently inactivated up to four sequential rounds of virus challenge. Our results show broad spectrum and long lasting anti-viral activity of AgCNP nanoparticles, due to targeting of viral surface proteins to disrupt interactions with cellular receptors. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Other, |