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Meeting 2024 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Continuous Flow Process of Surface-engineered, pH-responsive CeO2 Nanozymes With Tumour-killing Potency
Author(s) Sayoni Sarkar, Ajit Kulkarni
On-Site Speaker (Planned) Sayoni Sarkar
Abstract Scope Surface functionalized, oxygen vacancy (VO)-rich CeO2 nanostructures were fabricated utilizing an in-house designed continuous flow process, governed by the Lamer-mechanism mediated nucleation and growth to aid in suitable lab-to-field translation. The altered surface chemistry due to the presence of abundant VO was assessed by XPS, Raman, and EPR spectroscopy. The concentration of Ce3+, Ce4+ and surface VO determined through XPS spectral changes were estimated to be 51.6%, 48.4%, and 29%, respectively. The strained crystal lattice due to the presence of higher Ce3+ was observed in the Raman spectra (peak broadening and shift). Moreover, structure-property correlation revealed the appreciable pH-responsive peroxidase (more potent than natural horse radish peroxidase) and catalase enzyme-mimicking efficacy due to the higher Ce3+/Ce4+ helped in combating oxidative stress-related toxicity tested on HeLa (cancerous) cells. Thus, this low-cost, engineered-nanozyme harbours transformative potency for hitherto unreported, advanced, cancer mitigation through transferrin-mediated endocytosis and pH-responsive combinatorial therapeutic strategies.
Proceedings Inclusion? Planned:
Keywords Nanotechnology, Biomaterials, Process Technology


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