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Meeting 2024 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title H-14: siRNA and Cerium Oxide Delivery With Ultrasound-sensitive Nanobubbles for Bone Disease Treatment
Author(s) Pedram Sotoudehbagha, Elayaraja Kolanthai, Fei Wei, Craig Neal, Udit Kumar, Melanie Coathup, Sudipta Seal, Mehdi Razavi
On-Site Speaker (Planned) Pedram Sotoudehbagha
Abstract Scope Ultrasound-sensitive nanobubbles (NBs) loaded with Cathepsin K short interfering RNA (CTSK siRNA) and cerium oxide nanoparticles (CNPs) were synthesized to downregulate the expression of CTSK in osteoclasts and improve the bone formation of human bone marrow-derived mesenchymal stem cells (hMSCs). Results showed that co-delivery of 2.5 nM CTSK siRNA and 1 g/mL CNPs with NBs to hMSCs improved the alkaline phosphatase activity (ALP) and mineralization. The ALP activity and the optical density of alizarin red S (ARS) staining increased to 12.28 4.68% vs 3.31 0.61% for control (p < 0.05), and to 1.12 0.03 vs 0.41 0.02 for control (p < 0.001), respectively. Also, it reduced the number of TRAP-positive cells (15.4 3.49/mm2 vs 26.73 3.80/mm2 for the control, p < 0.01) in human osteoclast precursors which indicates lower osteoclastogenesis. Thus, this system can be a suitable carrier for bone treatment.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Nanotechnology, Other

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

A Nanoscale Perspective on Charge Carrier Transport in Melanin Biopigments for Sustainable Electronics
A Neoteric Antibacterial Silver-Ceria Nanozyme for Abiotic Surfaces
Aerosol Jet Printing MXenes: On-demand Manufacturing of Wearable Electronics
Architected Interfaces in Biological Systems that Mitigate Failure
Continuous Flow Process of Surface-engineered, pH-responsive CeO2 Nanozymes With Tumour-killing Potency
Durability Performance of Enzymatic Self-healing Concrete
Durable Enzymatic Construction Materials (ECM-σ)
Effect of Ice Nucleation Proteins on the Structure-property Relationships of Ice: A Combined Simulation and Experimental Approach
Enamel Formation: Bioinspired Interfacial Design
Exploring the 3-Dimensional Structure and Composition of Dental Enamel at the Nanoscale
H-10: Cooperative Surface Self-assembly Kinetics of Metal Binding Peptides by Spectral Rate Distribution
H-11: Low-cost Customizable 3D Printed Biohybrid Scaffolds
H-12: Machine Learning-guided Identification of Antimicrobial Peptides Targeting Oral Health
H-13: Multi-functional Peptide-polymer Hybrids for Dental Tissue Repair
H-14: siRNA and Cerium Oxide Delivery With Ultrasound-sensitive Nanobubbles for Bone Disease Treatment
H-15: The Nanoscale Interface and Structure Function Properties of Cortical Bone
H-7: Broad Spectrum, Potent and Durable Ceria Nanoparticles Inactivate RNA Virus Infectivity by Targeting Virion Surfaces and Disrupting Virus-receptor Interactions
H-8: Carbon Negative Deeply Structured Hierarchical Ceramics Derived From Biogenic Silica
H-9: Collagen Platform Exploring Antimicrobial Peptide-polymer Hybrids
Inkjet-printed Nanopatterned Aptasensors for Lateral Flow Detection of Foodborne Pathogens
Interpenetrating Polymer Network as Interface Material in Bioinspired Composites
Matrix Assisted Pulsed Laser Evaporation for Layer-by-Layer Processing of Thin Films for Biomedical Applications
Measuring and Calibrating Interfacial Forces at Hard and Soft Interfaces via Force Spectroscopy for Quantitative Materials Description
Mechanically and Biologically Tunable Biomaterials
Molecular Insights Into Mineral Nanoparticle Interactions With Proteins
Nanomechanical Mapping in Bone
Quantifying Surface Topographies on Antimicrobial Copper
Rapid Prototyping of Additively Manufactured Cell Culture Chambers With Integrated Nano-biosensors
Surface Modified Nanomaterials for Viral Interactions
Tailoring the Micro- and Nanostructure of Freeze-cast Scaffolds for Biomaterials
The Difference of Trabecular and Cortical Bone Material Properties at the Proximal Hip May Influence Bone Fragility
Towards Effective Therapies for Bone Metastasis of Breast Cancer Using Novel Phenolic Compounds

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