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Meeting 2024 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title H-14: siRNA and Cerium Oxide Delivery With Ultrasound-sensitive Nanobubbles for Bone Disease Treatment
Author(s) Pedram Sotoudehbagha, Elayaraja Kolanthai, Fei Wei, Craig Neal, Udit Kumar, Melanie Coathup, Sudipta Seal, Mehdi Razavi
On-Site Speaker (Planned) Pedram Sotoudehbagha
Abstract Scope Ultrasound-sensitive nanobubbles (NBs) loaded with Cathepsin K short interfering RNA (CTSK siRNA) and cerium oxide nanoparticles (CNPs) were synthesized to downregulate the expression of CTSK in osteoclasts and improve the bone formation of human bone marrow-derived mesenchymal stem cells (hMSCs). Results showed that co-delivery of 2.5 nM CTSK siRNA and 1 g/mL CNPs with NBs to hMSCs improved the alkaline phosphatase activity (ALP) and mineralization. The ALP activity and the optical density of alizarin red S (ARS) staining increased to 12.28 4.68% vs 3.31 0.61% for control (p < 0.05), and to 1.12 0.03 vs 0.41 0.02 for control (p < 0.001), respectively. Also, it reduced the number of TRAP-positive cells (15.4 3.49/mm2 vs 26.73 3.80/mm2 for the control, p < 0.01) in human osteoclast precursors which indicates lower osteoclastogenesis. Thus, this system can be a suitable carrier for bone treatment.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Nanotechnology, Other


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