|About this Abstract
||2020 TMS Annual Meeting & Exhibition
||Characterization of Minerals, Metals and Materials
||Characterization of a Brazilian Kaolin for its Use in the Controlled Release of Isoniazid
||Maria das Grašas da Silva Valenzuela, Jessica de Carvalho Arjona, Bianca Bottega Michel, Tatiana Oliveira Costa, Thamyres Carvalho Cardoso, Gilmar Oliveira Pinheiro, Margarita Rosa Bobadilla, Roberto de Freitas Neves, Francisco Rolando Valenzuela
|On-Site Speaker (Planned)
||Maria das Grašas da Silva Valenzuela
Tuberculosis is a neglected disease and was decreed as a global emergency by the World Health Organization since 1993. One of the most widely used medications for its treatment is isoniazid, but it has many side effects and high drop-out rates before the final treatment. Among the methods studied to minimize these problems is the controlled release, and one of the main candidate substrates are clays. In this work, a Brazilian kaolin was characterized aiming its use in the controlled release of isoniazid. Kaolin was characterized by techniques such as XRD, IR, thermal analysis and optical and electronic microscopies. The rheological properties of aqueous kaolin dispersions containing several water soluble organic solvents, such as ethanol and acetic acid, were studied, showing shear stress curves versus shear rates. The studied kaolin has shown potential as a controlled release agent for isoniazid.