|About this Abstract
||2020 TMS Annual Meeting & Exhibition
||Characterization of Minerals, Metals and Materials
||Synthesis of a Synthetic Clay for the Use of Controlled Isoniazid Release Systems
||Thamyres C. de Carvalho, Pinheiro Gilmar, Arjona Jessica, Valenzuela Maria das Grašas , Hildebrando Edemariino, Neves Roberto, Valenzuela-Diaz Francisco
|On-Site Speaker (Planned)
||Thamyres C. de Carvalho
Tuberculosis is the second infectious disease that cause most deaths in the world. Isoniazid is the drug most used in the treatment of tuberculosis, although it is toxic, and causes serious health risks. However, the intercalation of isoniazid to clay leads to the formation of the clay/isoniazid compound, constituting a controlled release system that can be used more efficiently than the current treatment model.
Faced with that possibility, in this study the Stevensite clay was synthesized using an hydrothermal method and characterized by X-ray Diffraction, Attenuated Infrared Spectroscopy and Scanning Electron Microscopies. The results showed that the synthetic clay presents patterns characteristic of Stevensite; its purity and controlled composition can facilitate its use in more specific applications, such as in the pharmaceutical area; and tests using this material as controlled release systems of the isoniazid drug have shown promising prospects.