|About this Abstract
||MS&T22: Materials Science & Technology
||3D Printing of Biomaterials and Devices
||Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
||Kalpana S. Katti, Krishna Kundu, Sharad V Jaswandkar, Dinesh R Katti
|On-Site Speaker (Planned)
||Kalpana S. Katti
An estimated four million bone grafting procedures are performed worldwide each year. Currently, therapies for non-union bone defects are limited. We report development of an interlocked BMP2 and BMP7 coated scaffold block-assembly using 3D printed molds. The interlocked block-assembly maintains high surface area while maintaining the scaffold's structural integrity. The BMPs coated scaffold blocks exhibit increased bone extracellular matrix (ECM) formation. Extended time (9-week) study on in-vitro bone regeneration using the BMPs coated interlocking scaffold blocks showed up to 120% increase in the elastic modulus indicating enhanced ECM formation. We report significant increase in the bone-related protein and osteogenesis related Wnt-factors in BMP coated scaffolds. The BMPs influence ECM formation much longer than the availability of the BMPs in culture-media suggesting that BMPs play a crucial role on initial stages of osteogenesis. Modular and manufacturable BMPs coated interlocking scaffolds made using 3D printed molds provides a novel bone regeneration system.