| Abstract Scope |
Implants use has expanded and with it,the prevalence of peri-implant disease that shortens implant life and leads to failure. Peri-implant disease results from microbiota dysbiogenesis triggering a host immune inflammatory response that destroys tissue. At an incidence of 14.5%, and over 3 million implants placed, growing by 500,000/year, reduced service life ending in failure will adversely impact public health and increase health care costs. We developed an antimicrobial bifunctional peptide film to slow disease progression. Based on a high-affinity titanium binding peptide that anchors the anti-microbial peptide to the implant surface, greater than 98% coverage is achieved in <2 minutes even in the presence of contaminating protein, to produce a film durable to mechanical brushing that kills >90% of bacterial. This non-surgical approach improves oral health by delivering a simple to apply/reapply multiple times using a water-delivered bifunctional peptide film serving to control microbial dysbiogenesis and reduce disease progression. |