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Meeting MS&T22: Materials Science & Technology
Symposium 3D Printing of Biomaterials and Devices
Presentation Title Selective Artificial Neural Network by Targeted Delivery of Neuronal Cells Using Magnetically Controlled 3D Printed Microrobots
Author(s) Hongsoo Choi
On-Site Speaker (Planned) Hongsoo Choi
Abstract Scope Several in vitro neural network models have been developed to mimic the reconstruction and interconnection of neural networks and to study brain function and related diseases. Here we report a 3D magnetically actuated microrobot fabricated by 3D laser lithography based on two-photon polymerization for selective neurite alignment and neuronal connections. Using confocal immunofluorescence imaging, the aligned neurite outgrowth and synaptic connections in the neural network were measured. The microrobot, in which the rat's primary hippocampal cells were cultivated, was transmitted between two neural clusters by a magnetic field and then structurally and functionally connected to a neural network that can transmit neural activity signals. Neuronal activities were measured with a MEA system to monitor the propagation of extracellular axonal signals from the neural clusters. The proposed microrobot shows the potential for in vitro neural experiments to understand how neurons communicate in the neural network by actively connecting neural clusters.
Proceedings Inclusion? Undecided

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

3-D Printing in Regenerative Engineering
3D Bioprinting with Engineered Living Materials for Advanced Biofabrication
3D Printing Integrated with Controlled Delivery for In Situ Tissue Engineering of Complex and Inhomogeneous Tissues from Endogenous Stem/Progenitor Cells
3D Printing of Nanomaterials-based Biomedical Electronics
3D Printing of Zonal-structured Scaffolds for Complex Tissue Engineering
3D Printing Strategies to Fabricate Complex Scaffolds for Tissue Engineering Applications
Additive Manufacturing Process Simulation of Polyetherimide Porous Scaffolds for Bone Tissue Engineering Applications
Biohybrid Functional Material Design by Engineered Peptides
C-1: Surface Treatment of Titanium by Alkali treatment and Magnesium Deposition for Orthopedic Application
Effect of Printing Parameters on 3D-printed Biodegradable Biopolymer-metal Composite Material
Effect of Sr2+ and Ca2+ ions on 3D printed Beta Tricalcium-Phosphate/Alginate Composite Scaffolds for Bone Tissue Engineering
Implant Optimization Guided by Biomimetic Insight
Interlocked Bone Scaffolds with BMP Induced Osteogenesis with Use of 3D Printed Molds
Laser-Based 3D Printing for Medical Applications
Mechanical and Electrical Properties of 3D Printed Wearable Structures
Periodic Cellular Ceramic Structures by Replication of Additive Manufactured Templates
Selective Artificial Neural Network by Targeted Delivery of Neuronal Cells Using Magnetically Controlled 3D Printed Microrobots
Sheet Lamination Additive Manufacturing (SLAM) – A Viable Approach to Resorbable 3D Constructs for Bone Tissue Engineering
Solvent Cast 3D Printing with Different Molecular Weight Polymers
The Regulatory Roles of the Substrate Microenvironment in Cancer Progression in Tissue Engineering Scaffolds

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