|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Curcumin Loaded Zinc – Fluorine Doped Hydroxyapatite for Osteoblast Growth, Osteosarcoma Inhibition, and Antibacterial Properties
||Arjak Bhattacharjee, Amit Bandyopadhyay, Susmita Bose
|On-Site Speaker (Planned)
Hydroxyapatite (HA) is an important material for bioactive coatings and scaffolds, utilized in bone tissue engineering applications. The flexible crystal chemistry of HA allows doping with both cations, and anions. In this work, zinc (Zn) and fluorine (F) are doped in HA to improve its osteogenic and antibacterial properties. Further, curcumin is loaded on top of the Zn-F- HA discs to investigate the chemo-preventive potential of this system against osteosarcoma. Our obtained results indicate that a combination of Zn and F increases the osteoblast cell viability on Zn-F-HA surface upto ~ 2 folds compared to control, due to the osteogenic potential of each dopant. The presence of curcumin leads to ~ 1.6 folds reduction in osteosarcoma viability due to the chemo-preventive potential of curcumin. This presentation will discuss curcumin release kinetics from the Zn-F-HA scaffold surface, and the effects of this drug delivery system on osteoblast proliferation, and osteosarcoma inhibition.
||Biomaterials, Ceramics, Surface Modification and Coatings