|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Nanoparticle Embedded Multifunctional Catheter for Multimodal Cancer Therapy
||Hiep Pham, Yufang He, Jonghyun Park
|On-Site Speaker (Planned)
Current state-of-the-art to achieve hyperthermal therapy involves injection of gold nanoparticles into the target cancerous site and subsequent irradiation with NIR light to produce heat by the surface plasmon resonance effect. However, challenges with this approach include poor heat localization due to particle migration, toxicity concerns, cost, and overall impracticality with combined therapies. These issues are addressed in this work, where biocompatible and cost-effective copper (II) sulfide (CuS) particles are embedded into a bioresorbable polymer catheter that produce therapeutic temperatures when irradiated with NIR light. The results of this work indicate that hyperthermia therapy can be made more practical using the CuS-embedded catheter and has to potential to ease combination of hyperthermal therapy with traditional cancer treatments, such as brachytherapy and chemotherapy, to enhance their therapeutic efficacy.