|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Mechanical Characterization of Collagen Hydrogels by Quasi-static Uniaxial Tensile Experiments
||JiEung Kim, Sangmin Lee, Taek-soo Kim, Dongchan Jang
|On-Site Speaker (Planned)
Given the significance of mechano-chemical interactions between the cells and extracellular matrices, the mechanical properties of collagen hydrogels are of essential importance in most biological systems. This study aims to investigate the tensile behavior of collagen hydrogels under quasi-static uniaxial tensile stress and provide its mechanical response. Strained confocal image under tension stage showed the structural evolution under uniaxial tension with lateral contraction. A combination of tensile testing and microstructure analysis demonstrates the mechanism of tensile properties complementarily. When the tensile stress is applied, the unfolding dominated deformation of the collagen network occurs in the first stage. Then, the mechanical response continuously turns to the stretching-dominated deformation of the network through the gradual transition regime between those two different mechanical responses. These results illustrate that collagen hydrogels respond to tensile stress with two main deformation mechanisms: unfolding dominated and stretching dominated regimes, which shows the non-linear stress-strain relationship.
||Biomaterials, Mechanical Properties,