|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Fabrication and Characterisation of Two-layered Synthetic Titanium-Chitosan Bone Scaffolds
||Lemiha Yildizbakan, Vasiliki C. Panagiotopoulou, Neelam Iqbal, Ngoc Do, Elena Jones, Peter V. Giannoudis, Animesh Jha, Dina Abdul Aziz
|On-Site Speaker (Planned)
Infection after bone fracture is a common complication that compromises the healing of the damaged bone and may even cause non-union. Infection can also affect the surrounding blood supply, influencing cell growth.
The aim of this study was to fabricate and characterize osteogenic and antibacterial bone-mimicking composite scaffolds.
The exterior, cortical-like, and porous part was fabricated using titanium powder with 10% iron-doped brushite mineral. The interior,trabecular-like part was fabricated from chitosan, iron-doped brushite, and cerium oxide. The cortical and trabecular components were integrated as one physical structure via freeze-drying. The scaffolds were characterized for their physico-chemical, structural, osteogenic, and antibacterial properties.
The minerals and multilayered scaffolds were characterized using light-based techniques (Raman, FTIR, UV-VIS spectroscopy), SEM, Zeta Potential, and X-ray diffraction. The osteogenic properties of the scaffolds were investigated using cytotoxicity and proliferation. The antibacterial properties of the scaffolds were studied against the most common bacteria in bone infection.
||Biomaterials, Characterization, Titanium