|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Multidrug Delivery via Electrospun Core-shell Structured Nanofibers for Enhanced Post-surgical Healing
||Hiep Pham, Gracie Boyer, Jonghyun Park
|On-Site Speaker (Planned)
In this work, a dual drug-loaded core-shell nanofiber enabled by electrospinning is developed. A fast-dissolving polymer loaded with a primary antibiotic drug serves as the thin shell and can achieve rapid drug delivery once immersed in an aqueous medium to suppress infections. Meanwhile, the core thermosensitive polymer serves dually as a stabilizing backbone to improve the spinnability of the shell and as a carrier to a secondary anti-inflammatory drug that can be released via a triggered rise in temperature. This temperature rise is triggered by the incorporation of magnetic nanoparticles in the core polymer, which produces heat once an alternating magnetic field is applied and creates openings in the core thermosensitive polymer enabling enhanced dissolution of the material and drug release. The electrospinning parameter impact is investigated and a characterization of dual drug-loaded core-shell structured nanofibers for drug delivery in relation to drug loading and drug release is conducted.