Plasmonic biosensors are considered to be highly promising for the development of simple, portable, sensitive, on-chip biodiagnostics for resource-limited settings. While there has been a tremendous progress in the rational design of plasmonic nanotransducers with high sensitivity and the development of hand-held read-out devices, the translation of these biosensors to resource-limited settings is hindered by the poor thermal, chemical and temporal stability of biorecognition elements. Degradation of the sensitive reagents and biodiagnostic chips compromises analytical validity, preventing accurate and timely diagnosis. In this talk, I will present the design and implementation of plasmonic biosensors that rely on ultrastable biorecognition elements. This approach overcomes the poor stability of existing plasmonic biosensors and takes them closer to real-world applications in resource-limited settings.